MicroRNA 526a-1 (miR-526a-1)

MicroRNA 526a-1 (miR-526a-1) is a short, non-coding RNA molecule belonging to the microRNA family and is involved in post-transcriptional regulation of gene expression. It functions by base-pairing with target mRNA molecules, leading to their degradation or translational inhibition. Most notably, miR-526a-1 has been identified as a tumor suppressor in hepatocellular carcinoma (HCC), where its expression is frequently downregulated in tumor tissues and cell lines compared to normal liver tissues. Overexpression of miR-526a-1 in HCC cell lines inhibits cellular proliferation, migration, and invasion, and decreases tumor growth in vivo. Mechanistically, miR-526a-1 targets and downregulates the oncogene p21-activated kinase 7 (PAK7), which is implicated in promoting tumorigenesis. Beyond cancer, miR-526a-1 is linked to antiviral responses and may participate in tuberculosis infection control. These features suggest its potential as both a therapeutic target and a biomarker for disease progression and treatment efficacy monitoring in HCC and possibly other diseases characterized by deregulated microRNA expression[1]. **Note:** No direct small-molecule drugs currently target miR-526a-1, and standard microRNA therapeutic strategies would involve either mimic or antagomir molecules, though none are approved for this specific microRNA as of the information provided.

Other names

hsa-mir-526a-1MIRN526A-1MIRN526A1MIR526A1