MicroRNA 526b (miR-526b)

MicroRNA 526b (miR-526b) is a small non-coding RNA molecule encoded in the chromosome 19 microRNA cluster (C19MC), the largest primate-specific miRNA cluster[1][2][3]. miR-526b is transcribed as part of a primary miRNA transcript, processed to a mature form that becomes incorporated into the RNA-induced silencing complex (RISC), where it mediates post-transcriptional suppression of gene expression by binding to complementary sequences in target mRNAs, typically leading to translation inhibition or degradation[3]. miR-526b has been shown to target genes such as MMP1 and Ku80, impacting processes like extracellular matrix remodeling, apoptosis, cell proliferation, and cancer pathways[1][3]. Upregulation and downregulation of miR-526b have been associated with various cancers, and it is mainly studied as a regulator or putative biomarker rather than a classical drug target[1][2][3].

Other names

hsa-miR-526bMIRN526BMIR526Bhsa-mir-526b