MicroRNA 532 (miR-532)

MicroRNA 532 (miR-532) is a small non-coding RNA molecule (~20–24 nucleotides) involved in post-transcriptional regulation of gene expression in multicellular organisms. It is transcribed as a primary miRNA, processed by Drosha and Dicer enzymes, and functions by incorporating into the RNA-induced silencing complex (RISC), where it binds to complementary sequences in target mRNA 3′ UTRs, leading to repression of protein synthesis or mRNA degradation. miR-532 has been implicated in controlling cell proliferation, apoptosis, inflammation, and migration. It can act as a tumor suppressor or oncogene in a tissue-specific manner, with altered expression in various cancers (e.g., renal, ovarian, liver, breast), cardiovascular conditions (e.g., atherosclerosis), and ischemic injuries. It also participates in host antiviral responses by targeting host viral replication co-factors. Its diverse roles in disease make miR-532 both a potential biomarker and a putative therapeutic target, though there are currently no approved drugs that specifically target or mimic miR-532 in clinical use.

Other names

hsa-mir-532MIRN532MIR532mir-532miR-532-5p

Not direct drug targeting; alters gene/protein expression by binding to 3′ UTRs of specific mRNAs (e.g., SESTD1, TAB3, PDCD4, BACH1, CXCL1, CSNK2A2), leading to translational inhibition or mRNA destabilization