MicroRNA 532-3p (miR-532-3p)

MicroRNA 532-3p (miR-532-3p) is a small, non-coding RNA molecule that serves as a critical post-transcriptional regulator of gene expression by binding to the 3' untranslated regions (UTRs) of target messenger RNAs. It primarily functions as a tumor suppressor in various malignancies, including colorectal cancer, lymphoma, and non-small cell lung cancer, where it inhibits cell proliferation, migration, and invasion while promoting apoptosis. miR-532-3p exerts these effects by silencing key oncogenic targets such as β-catenin, FOXM1, and FOXP3, thereby disrupting pathways like Wnt/β-catenin signaling. Beyond oncology, miR-532-3p is involved in cardiovascular and neurological health, offering protection against doxorubicin-induced cardiotoxicity and cerebral ischemia/reperfusion injury by modulating oxidative stress and apoptotic pathways. Although no drugs targeting miR-532-3p are currently FDA-approved, miR-532-3p mimics and inhibitors are being investigated as potential therapeutic agents to restore or modulate its activity in disease states. Furthermore, its presence in biofluids makes it a valuable non-invasive biomarker for cancer prognosis and drug-induced tissue injury.

Other names

hsa-miR-532-3pMIR532MicroRNA 532miR-532

RNA interference and post-transcriptional gene silencing by binding to the 3' untranslated region (UTR) of target mRNAs to repress translation or induce mRNA degradation.