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Target intelligence / Profile preview
MicroRNA 544b (MIR544B)
- Target
- MIR544B
- Molecular classification
- MicroRNA, Non-coding RNA, Epigenetic regulator
01
Overview
MicroRNA 544b (MIR544B) is a member of the microRNA precursor family, functioning as a post-transcriptional regulator. It is upregulated in several cancers, including colorectal cancer, where it promotes cell proliferation and invasion by targeting mRNAs such as forkhead box O1 (FOXO1)[1][4]. MIR544B influences cell cycle transition and may serve as an oncogenic miRNA, making it a potential therapeutic target and biomarker in oncology[1]. Experimental modulation of MIR544B (using mimics or inhibitors) is explored in molecular biology and preclinical cancer research[3][4].
- Other names
- hsa-mir-544bmir-544bMIR544B
02
Mechanism of action
Drugs or molecules (such as anti-miRs) inhibit or mimic MIR544B activity, affecting gene regulation (notably, suppression of tumor suppressor genes like FOXO1)
03
Biological functions
Regulation of gene expressionCell cycle progressionCell proliferationCell invasionCancer development and progression
04
Disease associations
Cancer (including colorectal, breast, lung, cervical, gastric, osteosarcoma, glioma)
05
Safety considerations
As with other miRNA-based therapies, challenges include off-target effects, delivery efficiency, and tissue specificityinhibition may disrupt normal gene regulatory networks
06
Interacting drugs
miRNA mimics
1 more in the full profile.
07
Biomarkers
Expression of MIR544B in tissues can serve as a biomarker for cancer progression, particularly in colorectal cancer
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