microRNA 548aa-1 (MIR548AA1)

microRNA 548aa-1 (MIR548AA1) is a member of the primate-specific miR-548 gene family, comprising over 70 individual miRNA genes dispersed across the human genome[1][4]. The MIR548AA1 gene produces a small non-coding RNA molecule involved in the post-transcriptional regulation of gene expression through RNA silencing mechanisms. The miR-548 family is poorly conserved, exhibits significant sequence divergence, and often originates from repetitive genomic elements. Members of this family, including MIR548AA1, have been associated with the regulation of signaling pathways, cytoskeletal dynamics, and inflammatory responses. Specifically, the miR-548 cluster, which includes MIR548AA1, has been shown to negatively regulate high mobility group box 1 (HMGB1) expression in human amniotic epithelial cells, implicating it in inflammatory processes and adverse obstetric outcomes such as preterm birth with chorioamnionitis[2]. Overall, microRNAs like MIR548AA1 act mainly as negative regulators of gene expression, but their specific biological targets and clinical significance remain under investigation[1][2][4].

Other names

hsa-mir-548aa-1hsa-miR-548aa-1MIR548AA1

Not applicable for drugs, but experimentally: synthetic miRNA mimics or inhibitors can modulate its repression of target mRNAs (e.g., HMGB1)