MicroRNA 548aa-2 (MIR548AA2)

MicroRNA 548aa-2 (MIR548AA2) is a member of the primate-specific miR-548 family of microRNAs, non-coding RNAs approximately 20-24 nucleotides in length that mediate post-transcriptional gene silencing in multicellular organisms[1][2]. These microRNAs are transcribed as part of primary transcripts that are processed by Drosha and Dicer enzymes into mature miRNA, which is incorporated into the RNA-induced silencing complex (RISC) to guide silencing of target mRNAs through imperfect base pairing, leading to translational inhibition or destabilization[1]. The miR-548 family—including 548aa-2—originated from Made1 miniature inverted-repeat transposable elements (MITEs), making these miRNAs primate-specific and highly divergent within the family, capable of targeting thousands of potential mRNAs[2][5]. Enrichment analyses of targets implicate miR-548 family members in regulation of actin cytoskeleton, MAPK, Wnt, p53, cell cycle, and cancer-related pathways[5]. Direct evidence supporting MIR548AA2 as a druggable or therapeutic target is lacking, and no drugs or clinical biomarker or safety data specific to this miRNA are currently reported[1][5]. **Notes:** - MIR548AA2 is not a classical therapeutic target (e.g., receptor, enzyme) but rather a regulatory RNA molecule associated with gene silencing. - All available data indicate it is a functionally significant miRNA family member with potential roles in human disease but not currently directly targeted by any approved drugs[1][2][5].

Other names

hsa-mir-548aa-2MIR548AA2GC17U901559GC17P065471NCBI Gene:100500895Ensembl:ENSG00000207688miRBase:hsa-mir-548aa-2