MicroRNA 548ad (MIR548AD)

MicroRNA 548ad is a short (about 20–24 nucleotides) non-coding RNA that functions as part of the broader miR-548 family. It regulates gene expression post-transcriptionally by binding to target mRNAs and altering their stability and translation, often leading to their inhibition or degradation[1]. Members of the miR-548 family, including MIR548AD, participate in diverse biological pathways such as actin cytoskeleton regulation, MAPK signaling, cell cycle control, and apoptosis[2]. The family is implicated in complex diseases, notably cancer (via modulation of epithelial–mesenchymal transition, migration, and invasion), inflammation, and disorders such as preterm birth[2][3][4]. MIR548AD is not a protein, enzyme, or traditional receptor, and there are currently no known drugs directly targeting this microRNA. Its relevance is more as a gene expression regulator and potential biomarker rather than a classical therapeutic target[1][2][3][4].

Other names

hsa-mir-548adMIR548AD