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Target intelligence / Profile preview
MicroRNA 548ag-1 (miR-548ag-1)
- Target
- miR-548ag-1
- Molecular classification
- Other (microRNA, non-coding RNA)
01
Overview
MicroRNA 548ag-1 (miR-548ag-1) is a short, non-coding RNA molecule in the microRNA family that functions mainly by post-transcriptional repression of target gene expression[3][1]. It acts as an oncogene in the development of obesity-related endometrial cancer by downregulating the tumor suppressor gene MOB1B, leading to deactivation of the Hippo pathway and enhanced tumor cell proliferation, invasion, and migration while inhibiting apoptosis[1][3]. Elevated levels of miR-548ag-1 are associated with poorer prognosis in endometrial cancer. It may serve as a biomarker for diagnosis and prognosis in specific cancer contexts, but is not currently considered a direct therapeutic receptor or enzyme target[1][3].
- Other names
- MIR548AG1hsa-mir-548ag-1miR-548ag
02
Biological functions
Post-transcriptional gene silencingRegulation of cell proliferationRegulation of apoptosisRegulation of invasion and migration
03
Disease associations
Cancer (specifically, acts as an oncogene in obesity-related endometrial cancer)
04
Safety considerations
None known as a direct drug target; microRNAs in general present challenges like off-target effects and delivery issues if considered for therapeutic modulation
05
Biomarkers
Potential diagnostic biomarker for obesity-related endometrial cancer
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