MicroRNA 548ai (MIR548AI)

MicroRNA 548ai (MIR548AI) is a short (approximately 20–24 nucleotide), non-coding RNA gene in humans, classified within the miR-548 family—a primate-specific, poorly conserved group of microRNAs[1][4][5]. MIR548AI is transcribed as part of a stem-loop precursor, processed by the Drosha and Dicer ribonucleases to give mature microRNA[1][5]. The mature MIR548AI is incorporated into the RNA-induced silencing complex (RISC), which engages target mRNAs via imperfect base-pairing, typically resulting in translational inhibition or mRNA destabilization[1][5]. The miR-548 family, including MIR548AI, is distributed across multiple chromosomes and likely evolved from transposable elements[4]. Specific studies implicate MIR548AI and its cluster in the negative regulation of the pro-inflammatory alarmin HMGB1, possibly modulating the pathogenesis of acute chorioamnionitis and preterm birth in humans[6]. While other members of the miR-548 family display functions in cell proliferation, apoptosis, migration, invasion, and cancer biology, evidence for direct roles—or therapeutic targeting—of MIR548AI itself in human diseases is currently limited[4][3].

Other names

MIR548AIhsa-mir-548aimicroRNA 548aimiR-548aimiR-548 cluster (as part of the miR-548 family, occasionally grouped with similar miRNAs such as miR-548aa, miR-548x-5p)

Not applicable (no drugs directly target MIR548AI).