MicroRNA 548al (MIR548AL)

MicroRNA 548al (MIR548AL) is a short, non-coding RNA belonging to the primate-specific, poorly conserved miR-548 family[2][3]. Like other miRNAs, MIR548AL is processed from a primary transcript and incorporated into the RNA-induced silencing complex (RISC) to regulate gene expression post-transcriptionally through imperfect base pairing with target mRNAs, leading to translational repression or mRNA destabilization[3]. While the miR-548 family members have been broadly implicated in cancer progression—modulating processes such as cell proliferation, apoptosis, migration, and invasion—the specific biological roles of MIR548AL itself remain largely uncharacterized in the literature[1][2]. No drugs target this microRNA directly; its main scientific interest lies in gene network regulation and possible biomarker utility, though it is not yet used clinically. Note: Most of the detailed functional, disease, and biomarker information available in the literature applies to other miR-548 family members (e.g., miR-548m), not specifically MIR548AL. If high specificity for MIR548AL itself is required for research or clinical use, this should be interpreted as a molecule with currently limited direct evidence and utility[1][2][3].

Other names

hsa-mir-548alMIR548ALMicroRNA 548almiR-548al

Not applicable. As a regulatory RNA, if targeted, the mechanism would be modulation of gene silencing or derepression through inhibition, replacement, or mimicry of the miRNA function.