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Target intelligence / Profile preview
MicroRNA 548az (MIR548AZ)
- Target
- MIR548AZ
- Molecular classification
- microRNA (miRNA), Non-coding RNA (ncRNA), Small regulatory RNA
01
Overview
MicroRNA 548az is a small, non-coding RNA molecule in humans encoded by the MIR548AZ gene. Like other miRNAs, it regulates gene expression post-transcriptionally by base pairing with complementary sequences in target mRNA molecules, primarily resulting in translational repression or mRNA degradation. MIR548AZ is a member of the large, primate-specific miR-548 family, which originates from transposable elements called Made1. It has been experimentally linked to cellular senescence (by repressing KATNAL1), and miR-548 family members have been implicated in cancer regulation and potentially serve as disease biomarkers. No approved drugs currently target MIR548AZ, but synthetic mimics are used for experimental modulation[1][3][5][9][11].
- Other names
- hsa-mir-548azmicroRNA mir-548azMIR548AZMIR548AZ gene
02
Mechanism of action
Synthetic RNA mimics of miR-548az may be used experimentally to upregulate its natural function in gene silencing[4].
03
Biological functions
Post-transcriptional gene silencingRegulation of mRNA stability and translationControl of cell proliferation and senescence (based on direct studies of miR-548az-5p)
04
Disease associations
Cancer (The miR-548 family shows altered expression in several cancers and is implicated in regulating tumor-associated genes[1][3].)Cellular senescence and possibly labor induction (by targeting KATNAL1 and inducing amniotic epithelial cell senescence)[3]Other (non-specific to inflammation, neurodegeneration, or cardiovascular diseases, but miRNAs in general may play roles in these)[12]
05
Safety considerations
As an endogenous miRNA, no therapeutic safety concerns are described, but off-target gene regulation and difficulties in delivery are general challenges in miRNA-based therapies.
06
Biomarkers
Altered miR-548 family expression is studied as a potential cancer biomarker and for monitoring cell senescence (e.g., amniotic epithelial cell senescence)[3].
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