MicroRNA 548f-2 (MIR548F2)

MicroRNA 548f-2 (MIR548F2) is a small non-coding RNA molecule (miRNA) that plays a role in the post-transcriptional regulation of gene expression in multicellular organisms[1]. It is transcribed from its gene locus as a precursor that undergoes enzymatic processing (by Drosha and Dicer) to yield a mature miRNA, which is incorporated into the RISC complex. The mature miRNA regulates cellular pathways by binding to complementary sequences in target mRNAs, leading to translational repression or mRNA degradation[1]. Emerging evidence implicates the miR-548F family (including miR-548F-2 and closely related members) in cancer biology, particularly in processes such as cell cycle control, proliferation, and cytoskeletal organization, with strong evidence in triple-negative breast cancer. However, direct evidence on MIR548F2-specific mechanisms and disease associations remains limited; most functional and disease associations are extrapolated from family members and broader miRNA research[2].

Other names

hsa-mir-548f-2MIRN548F2MIR548F-2MIR548F2

MicroRNA-mediated gene silencing; RNA-induced silencing complex (RISC) targeting of mRNAs for degradation or translational repression[1]