MicroRNA 548f-3 (MIR548F3)

MicroRNA 548f-3 (MIR548F3) is a small, non-coding RNA molecule (20–24 nucleotides) that regulates gene expression at the post-transcriptional level, primarily by inhibiting the translation or promoting the degradation of specific messenger RNAs (mRNAs)[2][5]. It is transcribed as part of a primary miRNA transcript, processed by Drosha and Dicer enzymes, and then incorporated into the RNA-induced silencing complex (RISC), where it guides the complex to target mRNAs via imperfect base pairing[2][5]. MIR548F3 has been shown to play regulatory roles in key cellular pathways, including cell cycle progression and spindle assembly checkpoint signaling. Recent research highlighted MIR548F3 (specifically, miR-548F-3p, its mature form) as significantly down-regulated in triple-negative breast cancer and implicated it in the regulation of several hub genes linked to this cancer’s pathogenesis[1]. Its tissue expression is highest in the retina, with moderate expression in the cerebellum. There is no current evidence for direct drug targeting or approved therapeutics involving MIR548F3, but it shows potential as a biomarker and therapeutic target, especially in certain cancers such as triple-negative breast cancer[1][2].

Other names

hsa-mir-548f-3MIR548F-3MIRN548F3MIR548F3