MicroRNA 548g (miR-548g)

MicroRNA 548g (miR-548g) is a member of the large and structurally diverse miR-548 family, which represents a group of poorly conserved, primate-specific microRNAs[6]. Like other microRNAs, miR-548g is a short non-coding RNA molecule (~22 nucleotides) that regulates gene expression at the post-transcriptional level, typically by binding the 3’ untranslated region (UTR) of target mRNAs and repressing their translation or promoting degradation[4]. miR-548g has been studied primarily in the context of cancers, where it may act as a tumor suppressor (inhibiting migration, invasion, and EMT by targeting relevant genes such as the aryl hydrocarbon receptor in breast cancer) or as an oncogenic miRNA in other settings[1][2]. It is not a receptor, enzyme, transporter, or other classical “druggable” protein target, but it may provide a future avenue for therapeutic intervention or serve as a disease biomarker in oncology. No drugs targeting miR-548g are approved, though experimental modulation with miRNA mimics or inhibitors is an area of active research[1][2].

Other names

miR-548gMIR548Ghsa-miR-548gMIRN548G

Not established; microRNAs such as miR-548g are sometimes modulated in research settings using mimics (to increase levels) or inhibitors/antagomirs (to decrease levels), but these are tools, not approved drugs.