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Target intelligence / Profile preview
microRNA-548j (miR-548j)
- Target
- miR-548j
- Molecular classification
- Other (microRNA, small non-coding RNA)
01
Overview
microRNA-548j (miR-548j) is a member of the primate-specific miR-548 family of small non-coding RNAs derived from transposable elements. It functions primarily as a regulator of gene expression via post-transcriptional silencing. miR-548j is notable for its role in promoting breast cancer cell invasion and metastasis by directly targeting the mRNA of Tensin1, a focal adhesion protein, thereby activating the Cdc42 signaling pathway that governs cell motility and cytoskeletal organization. Elevated expression of miR-548j is associated with increased invasiveness in breast cancer cell lines and correlates with poorer prognosis and higher rates of metastasis in clinical samples. Additional evidence suggests regulatory roles in angiogenesis and possible involvement in other diseases, but its principal biological significance appears to be as an epigenetic modulator of cancer progression, with potential as a biomarker and hypothetical therapeutic target.
- Other names
- hsa-mir-548jMIRN548JMIR548JMIR548J-3pmiR-548j-5p
02
Mechanism of action
Not applicable (microRNA; no approved therapeutic agents directly target miR-548j)
03
Biological functions
Regulation of gene expression (post-transcriptional)Promotion of cancer cell invasionRegulation of metastasisNegative regulation of Tensin1 and modulation of Cdc42 pathwayRegulation of angiogenesis
04
Disease associations
Cancer (notably breast cancer metastasis)Possible roles in other tumor types, such as glioblastoma (as part of the miR-548 family)Peripheral artery disease (angiogenesis)
05
Safety considerations
None established (as a microRNA, safety concerns would arise in development of inhibitors, mimics, or anti-miR agents in therapy; no drugs targeting this microRNA reported in clinical use)
06
Interacting drugs
None known
07
Biomarkers
Prognostic biomarker for breast cancer metastasis and survival (expression level correlates with metastasis and patient outcome)Potential biomarker in peripheral artery disease (regulation of angiogenesis)
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