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Target intelligence / Profile preview
MicroRNA 548k (MIR548K)
- Target
- MIR548K
- Molecular classification
- MicroRNA (miRNA), Non-coding RNA
01
Overview
MicroRNA 548k (MIR548K) is a short, non-coding RNA molecule derived from a large, primate-specific miRNA family. It regulates gene expression by binding target mRNAs and inhibiting their translation or promoting their degradation. The MIR548 family members have heterogeneous 'seed sequences' due to evolutionary origin from transposable elements. MIR548K has been implicated in promoting cancer cell growth and mobility, with suggestive roles as an oncomiR particularly in esophageal squamous cell carcinoma. Its expression and function are still being characterized, but current evidence supports its importance in cell invasion, metastasis modulation, and possible utility as a clinical biomarker. The scientific understanding of MIR548K remains less developed than major miRNAs, but evolving evidence supports further investigation into its biological roles and potential as a therapeutic or diagnostic target.
- Other names
- MIR548Khsa-mir-548kMIRN548K
02
Mechanism of action
Drugs/therapies would act by modulating MIR548K’s expression or function to influence target mRNA translation or stability.
03
Biological functions
Post-transcriptional gene regulationRegulation of cell proliferationModulation of metastasis and cell mobility
04
Disease associations
Cancer (notably esophageal squamous cell carcinoma, breast cancer)Cardiovascular disease (potential biomarker for heart failure, though not directly shown for MIR548K but for family members)
05
Safety considerations
Off-target effectsRNA interference-related immune activationGeneral challenges of delivering miRNA-based therapies to specific tissues
06
Biomarkers
MIR548 family members, including possibly MIR548K, are considered candidate biomarkers for cancer progression and heart failure
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