MicroRNA-548m (miR-548m)

MicroRNA-548m is a member of the miR-548 family, consisting of short, non-coding RNAs that regulate gene expression post-transcriptionally. In cancer biology, miR-548m acts as a modulator of epithelial–mesenchymal transition (EMT), migration, and invasion, especially in breast cancer cells. Its expression is generally downregulated in primary breast tumors, particularly the triple-negative subtype, and experimental overexpression inhibits EMT markers (such as SNAI1, SNAI2, ZEB1, ZEB2) and matrix metallopeptidase 9 (MMP9)[1][2][3]. The best-studied direct mRNA target is the aryl hydrocarbon receptor (AHR), a transcription factor involved in cell adhesion and migration. miR-548m has roles in tumor suppression in breast cancer and lymphoma, but its effect can vary by tissue and context. No drugs are known to directly interact with or target miR-548m[1][2][3][4].

Other names

hsa-miR-548mMIRN548MMIR548M

Not drug-targeted; functions by sequence-specific repression of target mRNAs (notably aryl hydrocarbon receptor/AHR) via RNA interference mechanisms