MicroRNA 548p (MIR548P)

MicroRNA 548p (MIR548P) is a member of the mir-548 precursor family, classified as a microRNA (miRNA), a short (20-24 nucleotide) non-coding RNA molecule with key roles in post-transcriptional regulation of gene expression in multicellular organisms. It is generated from stem-loop precursors via the Drosha and Dicer nucleases. Mature miR-548p integrates into the RNA-induced silencing complex (RISC), and recognizes target mRNAs by imperfect base pairing, usually resulting in mRNA degradation or translational inhibition. MIR548P is notably involved in metabolic regulation—by reducing lipoprotein and lipid synthesis in the liver through suppression of ApoB, HMGCR, and ACSL4—and can modulate inflammatory responses in amniotic epithelial cells by regulating HMGB1 expression. These biological roles implicate MIR548P in diseases such as hyperlipidemia, atherosclerosis, hepatosteatosis, and possibly certain inflammatory and cancerous conditions. No evidence supports that MIR548P is a direct receptor or classical target for small-molecule drugs. It is correctly classified as a microRNA, not a protein-coding gene or receptor. Expression and function are context-dependent, relevant mainly as a regulator and potential biomarker, not as a direct drug target.

Other names

hsa-mir-548pMIRN548PMIR548PMicroRNA 548p

If targeted therapeutically, potential mechanisms would involve modulating miR-548p levels to influence the stability and translation of target mRNAs (e.g., using antagomirs or miRNA mimics). For example, increasing miR-548p would suppress ApoB and HMGB1 expression, impacting lipid metabolism and inflammation