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Target intelligence / Profile preview
MicroRNA 551a (miR-551a)
- Target
- miR-551a
- Molecular classification
- microRNA, Non-coding RNA, Other
01
Overview
MicroRNA 551a is a small non-coding RNA molecule that functions in post-transcriptional regulation of gene expression by binding to target messenger RNAs (mRNAs), leading to their degradation or translational repression[1][2][5]. miR-551a participates in the regulation of tumor cell survival, especially in the context of chemotherapy resistance—for example, by promoting resistance to 5-fluorouracil-induced cell death via downregulation of MEF2C and affecting cellular stemness (sphere formation)[2]. It is also reported as a tumor suppressor in specific cancers, notably by directly targeting oncogenes such as PRL-3, IRS2, and CKB[3][5]. Aberrant expression of miR-551a has pathological implications in cancer development and drug resistance, making it a molecule of interest as a potential therapeutic target and biomarker for oncology research[2][3][5].
- Other names
- MIR551Ahsa-mir-551aMIRN551Amir-551a
02
Mechanism of action
Drug resistance modulation via gene silencing: miR-551a regulates targets like MEF2C, PRL-3, and IRS2, impacting stemness and chemotherapy response
03
Biological functions
Regulation of gene expressionCell survivalStemness and sphere formationResistance to apoptosisCell proliferation (indirectly)
04
Disease associations
Cancer (notably gastric, colon, ovarian, and hepatocellular carcinoma)Drug resistance (especially to 5-fluorouracil)
05
Safety considerations
Therapeutic targeting of miR-551a may impact multiple gene networks, as microRNAs typically have diverse targets.Risk of off-target effects due to broad regulatory function.
06
Interacting drugs
5-fluorouracil (5-FU)
07
Biomarkers
Potential biomarker for cancer drug resistancePotential biomarker for tumor suppressor activity in gastric cancer
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