microRNA 564 (miR-564)

microRNA 564 (miR-564) is a small non-coding RNA molecule that regulates gene expression post-transcriptionally by binding to complementary sequences in target messenger RNAs (mRNAs), leading to their degradation or inhibited translation. miR-564 acts as a tumor suppressor in various cancer types. It is frequently downregulated in multiple human tumors, including papillary thyroid cancer, non-small cell lung cancer, breast cancer, gastric carcinoma, osteosarcoma, glioblastoma, prostate cancer, and hepatocellular carcinoma. Overexpression of miR-564 suppresses tumor cell proliferation, migration, and invasion and promotes apoptosis by targeting key oncogenes and signaling axes such as PI3K/AKT, MAPK, PTEN/Akt, and cell cycle regulators. It has been studied as a prognostic biomarker (e.g., in breast and thyroid cancers) and as a candidate therapeutic target for restoring tumor suppressor activity in cancer therapy, though direct clinical interventions or drugs targeting miR-564 have not been approved or widely reported.

Other names

hsa-miR-564MIR564MIRN564hsa-mir-564

Indirect, via repression of oncogenes and key signaling nodes (e.g., AEG-1, AKT2, GNA12, GYS1, SRF, E2F3, TGF-β1, plexin A4) by direct binding to target mRNA 3'UTRs, leading to mRNA degradation or translational inhibition