MicroRNA-567 (miR-567)

MicroRNA-567 (miR-567) is a small, endogenous non-coding RNA belonging to the microRNA family, involved in post-transcriptional regulation of gene expression. miR-567 functions primarily as a tumor suppressor in several cancer types. Its expression is significantly reduced in non-small cell lung cancer, breast cancer with poor prognosis, and colorectal cancer. Upregulation of miR-567 inhibits tumor cell proliferation, induces cell apoptosis, causes cell cycle arrest, and suppresses migration and angiogenesis[1][3][4]. Identified direct mRNA targets include cyclin-dependent kinase 8 (CDK8) in lung cancer, karyopherin subunit alpha 4 (KPNA4) in breast cancer, and vascular endothelial growth factor A (VEGFA) in colorectal cancer. These regulatory interactions underlie its tumor suppressive actions and its potential as a prognostic biomarker and therapeutic target in oncology[1][3][4]. There are currently no approved drugs targeting miR-567, but it is considered a candidate for RNA-based therapeutic intervention.

Other names

hsa-miR-567MIRN567MIR567

Post-transcriptional regulation of gene expression by binding to target mRNAs such as CDK8, KPNA4, and VEGFA, leading to mRNA degradation or translational inhibition[1][3][4].