MicroRNA 5692c-2 (MIR5692C2)

MicroRNA 5692c-2 (MIR5692C2) is a small, non-coding RNA molecule within the microRNA family. Like other microRNAs, it functions as a post-transcriptional regulator of gene expression by binding to partially complementary sequences in the 3′ untranslated region of target mRNAs, leading to translation inhibition or mRNA degradation[1]. MIR5692C2 has been shown to interact directly with the 3′ UTR of PTEN (Phosphatase and tensin homolog) mRNA. This interaction results in the downregulation of PTEN protein expression and subsequent enhancement of AKT and ERK1/2 kinase phosphorylation, promoting cell survival, particularly in human CD34^+^ endothelial cells exposed to ischemic conditions[2]. Gene ontology analysis indicates its involvement in inflammatory signaling pathways in endothelial cells, suggesting a putative role in tissue regeneration and vascular inflammation[2]. There are currently no known drugs in clinical use that directly target MIR5692C2 or use it as a biomarker. It is not classified as a canonical receptor, enzyme, transporter, or classic therapeutic protein target, but is a regulatory RNA modulator with emerging biological interest, especially in vascular biology. Limitations: There is very limited direct literature on MIR5692C2; most available data are indirect or from mechanistic cell studies, and some alias confusion may occur with similarly named microRNAs. It is not established as a standardized clinical drug target as of 2025[2].

Other names

hsa-mir-5692c-2MIR5692C2miR-5692c

Suppresses expression of target genes (not by direct drug interaction, but RNA interference). Specifically shown to target the 3′ UTR of PTEN mRNA, leading to reduced PTEN protein and increased survival/pro-survival kinase signaling (AKT, ERK1/2) in endothelial cells.