Target intelligence / Profile preview

microRNA 5698 (miR-5698)

Target
miR-5698
Molecular classification
Non-coding RNA, MicroRNA, RNA gene regulator
01

Overview

microRNA 5698 (miR-5698) is a member of the human microRNA family, encoding a short non-coding RNA that primarily regulates gene expression at the post-transcriptional level via the RNA-induced silencing complex (RISC)[4]. It has been identified as a key component of the miRNA-mRNA regulatory network in lung adenocarcinoma, where it controls several hub genes involved in immune cell adhesion and cytotoxicity, tumor cell proliferation, and cell death[1]. miR-5698 is considered a promising biomarker for cancer prognosis and may inform future therapeutic strategies, either as a direct target or in monitoring response to treatment (for example, in metastatic breast cancer)[1]. Like other microRNAs, its broader functional role includes facilitating the finely tuned regulation of transcriptome dynamics, with implications in cell proliferation, immune responses, and apoptosis[3][4][6].

Other names
MIR5698miR-5698hsa-miR-5698
02

Mechanism of action

Not directly targeted by drugs yet; acts through the RNA-induced silencing complex (RISC) to regulate gene expression. Its modulation impacts oncogene and tumor suppressor pathways by targeting mRNAs involved in immune cell adhesion, cytotoxicity, and tumor proliferation.

03

Biological functions

Regulation of gene expression (post-transcriptional silencing/degradation)Cell proliferationCell death (apoptosis)Immune response modulationTumorigenesis control
04

Disease associations

Cancer (specifically lung adenocarcinoma and possibly breast cancer as a biomarker)Prognostic biomarker (e.g., breast cancer metastasis)
05

Safety considerations

No notable safety concerns specific to miR-5698 have been documented. General challenges with microRNA therapeutics include off-target effects and delivery specificity.
06

Biomarkers

Serum miR-5698 levels may be used as biomarkers for LUAD prognosisPredicting eribulin response and distant metastasis in breast cancer

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