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Target intelligence / Profile preview
microRNA 5703 (miR-5703)
- Target
- miR-5703
- Molecular classification
- microRNA, non-coding RNA, gene regulator, Other
01
Overview
microRNA 5703 (miR-5703, also known as hsa-mir-5703 or MIR5703) is a small, non-coding RNA molecule belonging to the microRNA family, which functions chiefly in the post-transcriptional regulation of gene expression. miR-5703 directly targets messenger RNAs to repress translation or induce degradation, impacting cellular pathways. Specifically, miR-5703 is implicated in suppressing tumor growth and metastasis in liver cancer by downregulating the SRC-FAK-FOXO1 axis and influencing cell proliferation and migration[1]. In ovarian carcinoma, miR-5703 is aberrantly expressed in cancer stem-like spheres and is considered a candidate biomarker for these cell populations; its precise functional effects in tumor development and progression remain to be fully characterized[2]. There is currently no evidence that miR-5703 is the direct target of any clinically approved drugs, nor that it is used as a biomarker in standard clinical practice.
- Other names
- miR-5703hsa-mir-5703MIR5703mir-5703
02
Biological functions
Post-transcriptional gene regulationCell proliferationCell migrationCell invasionTumor suppressionOther
03
Disease associations
Cancer (liver cancer, ovarian carcinoma)Potential biomarker in stem-like cancer cellsOther
04
Biomarkers
Putative marker for cancer stem-like cells in ovarian carcinoma[2]Linked to liver cancer progression and prognosis as a marker (tumor growth/metastasis via SRC-FAK-FOXO1 pathway)[1][2]
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