microRNA 572 (miR-572)

microRNA 572 (miR-572) is a small, non-coding RNA molecule of the microRNA family that regulates gene expression post-transcriptionally by binding to complementary sequences in the 3’ untranslated regions of target mRNAs[3][5]. MiR-572 is implicated in the promotion of cell proliferation, inhibition of apoptosis, and increased cell migration and invasion in various cancers, functioning as an oncogene in renal cell carcinoma, ovarian cancer, and prostate cancer by targeting tumor suppressor genes such as PTEN, SOCS1, p21, and PPP2R2C[2][6]. In the nervous system, miR-572 has been shown to regulate neuronal plasticity and cognitive function by targeting NCAM1, and has been proposed as a biomarker for early detection of post-operative cognitive dysfunction[4]. The broad regulatory activity of miR-572, common to miRNAs, presents both therapeutic opportunities and challenges, particularly in terms of delivery and off-target effects[1].

Other names

hsa-mir-572MIRN572hsa-miR-572MIR572

Regulation of mRNA targets by binding to 3’ untranslated regions, leading to mRNA degradation or translational inhibition (common to microRNAs)[3][4]; Inhibition of target genes such as PTEN (tumor suppressor in prostate cancer)[6], SOCS1 and p21 (in ovarian cancer)[2], and NCAM1 (in neuronal tissue)[4]