MicroRNA 573 (miR-573)

MicroRNA 573 (miR-573) is a small, non-coding RNA molecule that regulates gene expression post-transcriptionally by binding complementary sequences in target mRNAs, leading to either translational repression or transcript degradation. It belongs to the microRNA class of small regulatory RNAs. MiR-573 acts as a negative regulator of cell proliferation, migration, and invasion—particularly shown in cutaneous squamous cell carcinoma and breast cancer—implying a tumor suppressor function. In endothelial cells, miR-573 expression mitigates endothelial permeability and inflammation (notably during Dengue virus infection) by targeting genes such as ANGPT2 and TLR2. MiR-573 is downregulated in various disease contexts, and its overexpression can reverse pathological changes in vitro. While miR-573 is not a therapeutic target like receptors or enzymes, it is considered a regulator or biomarker in research related to cancer, infection, and inflammatory diseases[1][3][5][6][7][9].

Other names

hsa-miR-573MIR573MIRN573mir-573

MicroRNA 573 binds target mRNAs at the 3' untranslated region (UTR) to suppress translation or promote degradation. It downregulates key targets (e.g., ANGPT2, TLR2). It functions via negatively regulating relevant mRNA expression which affects cellular phenotypes.