MicroRNA 5739 (miR-5739)

MicroRNA 5739 (miR-5739) is a human microRNA (non-coding RNA) that plays an essential role in embryonic mesoderm development, specifically controlling the proliferation, differentiation, and maturation of muscle and vascular cell lineages through post-transcriptional gene silencing. It acts by binding the 3′ untranslated regions of target mRNAs to suppress their expression, directly regulating key genes such as SMA, Brachyury T, Hand1 (in muscle lineage), and KDR and Endoglin (in vascular lineage). Experimental knockout of miR-5739 in human embryonic stem cells leads to profound defects in muscle and blood vessel formation, while its expression is markedly decreased in pathological tissues from patients with both congenital muscle and vascular diseases. These functions highlight miR-5739 as a promising candidate for cell therapy research in genetic diseases and as a novel biomarker for diagnosis and monitoring of muscle/vascular pathologies.

Other names

hsa-mir-5739microRNA mir-5739MIR5739

Binds to target gene 3′ untranslated regions to suppress expression via RNA interference (canonical miRNA action). Targets specific genes for muscle (SMA, Brachyury T, Hand1) and vascular (KDR, Endoglin) differentiation.