MicroRNA-576 (miR-576)

MicroRNA-576 (miR-576) is a primate-specific, small non-coding RNA belonging to the microRNA family. It is encoded by the MIR576 gene (also referred to as hsa-mir-576 in humans). MiR-576 functions by regulating mRNA stability and translation through binding to complementary sequences in target mRNAs. It exists as two mature forms: miR-576-3p and miR-576-5p, which may have distinct or overlapping biological effects. - miR-576-3p acts as a regulator of host antiviral response by negatively regulating critical pathway proteins such as STING, MAVS, and TRAF3, thereby modulating type I interferon (IFN) expression and setting the threshold for antiviral defense, likely to prevent excessive inflammation[2]. - In cancer, miR-576-3p can function as a tumor suppressor by inhibiting migration and angiogenesis of glioma cells, in part via targeting HIF-1α[1], while miR-576-5p may act as an oncomiR, shown to enhance invasion and correlate with aggressive growth in melanoma cells, possibly via indirect upregulation of pro-survival and invasion-associated proteins such as MCL1 and BCL9[3]. - Differential expression of miR-576 family members has been associated with certain cancers and inflammatory diseases, suggesting their potential as disease biomarkers, but no direct therapeutic or pharmaceutical targeting agents have been reported to date[1][2][3]. - MicroRNA-576 is not a receptor, enzyme, transporter, or typical therapeutic “target” in the classical drug development sense, but is a regulatory RNA influencing disease-related signaling pathways.

Other names

MIR576hsa-mir-576MIRN576miR-576-3pmiR-576-5p