microRNA 577 (miR-577)

microRNA 577 (miR-577) is a small non-coding RNA, approximately 22 nucleotides long, encoded on chromosome 4q26. It regulates gene expression post-transcriptionally by binding to complementary sequences in target mRNA 3' untranslated regions (3'UTRs), resulting in mRNA degradation or translational inhibition[5]. miR-577 has diverse and context-dependent functions in cancer biology. - In **gastric cancer**, miR-577 is upregulated by TGF-β via NF-κB and promotes epithelial-mesenchymal transition (EMT), metastasis, and chemoresistance, forming a feed-forward loop with SDPR/ERK/NF-κB signaling[1]. - In **non-small cell lung cancer** (NSCLC) and **colorectal cancer**, miR-577 is frequently downregulated and exerts tumor-suppressive effects by inhibiting proliferation, invasion, EMT, and specific target proteins such as WNT2B, HOXA1, and HSP27[2][3][4][6][7]. - Roles in other cancers (glioblastoma, osteosarcoma, esophageal carcinoma) have also been reported, where miR-577 either promotes or suppresses malignant phenotypes depending on cellular context[1][4]. There are currently no clinically approved drugs that directly target miR-577, though it is under active investigation as a therapeutic target and biomarker in cancer, with experimental approaches focusing on oligonucleotide-based modulation[1][2][3][4][7].

Other names

miR-577MIR577hsa-mir-577MIRN577mir-577

miR-577 suppresses or promotes gene expression by binding to target mRNA 3’UTRs, resulting in mRNA degradation or translational inhibition. Acts as a tumor suppressor or oncogene depending on cancer type: For example, suppresses WNT2B in NSCLC, HSP27 in colorectal cancer, HOXA1 in lung cancer