MicroRNA 578 (miR-578)

MicroRNA 578 (miR-578) is a short, non-coding RNA molecule belonging to the family of microRNAs, which are key post-transcriptional regulators of gene expression. miR-578 is predominantly recognized for its role in the negative regulation of angiogenesis and cell proliferation through the targeting of mRNAs encoding angiogenesis-associated proteins such as VEGFA, FAK, ANGPT2, and HIF1A. Clinically, miR-578 is downregulated in BRCA1/2-related breast cancers and osteosarcoma, implicating it as a tumor suppressor miRNA in these contexts[1][3]. Like other microRNAs, miR-578 acts by binding to complementary sequences in the 3′ untranslated regions (3′UTR) of target messenger RNAs, resulting in translational repression or mRNA degradation[2][5]. Interest in miR-578 as a therapeutic biomolecule arises from its regulatory capacity in pathways relevant to cancer progression, although no drugs directly targeting miR-578 are currently in clinical use[2].

Other names

hsa-miR-578MIR578MIRN578hsa-mir-578

Binds to 3' untranslated regions of target mRNAs to inhibit their translation or promote their degradation[2][5]; Negatively regulates angiogenesis-associated genes such as VEGFA, angiopoietin-2 (ANGPT2), focal adhesion kinase (FAK), and hypoxia inducible factor-1 alpha (HIF1A)[1][3]