MicroRNA 582 (MIR582)

MicroRNA 582 (MIR582) is a human non-coding RNA gene that produces two mature microRNAs: hsa-miR-582-5p and hsa-miR-582-3p[1][2]. These small regulatory RNAs play post-transcriptional roles in gene silencing, impacting mRNA stability and translation[3]. MIR582 is implicated in multiple biological functions including regulation of cell proliferation, apoptosis, and maintenance of stemness in both cancer stem cells and neural stem cells[1][3]. In cancer, miR-582-5p and miR-582-3p have been shown to both suppress and promote tumor progression depending on the context, for example, by targeting oncogenic pathways (including NOTCH1 and Hippo-YAP/TAZ) or enhancing epithelial-mesenchymal transition (EMT)[1][4][5][6][7]. The molecule serves as a biomarker for tumorigenicity and may represent a novel therapeutic target, though no approved drugs directly target MIR582 to date. Safety concerns involve the broad regulatory functions of microRNAs, raising issues for off-target effects and the impact on normal stem cell function[3].

Other names

hsa-mir-582MIRN582hsa-miR-582-3phsa-miR-582-5p

Regulates gene expression by binding to target mRNAs, leading to mRNA degradation or repression of translation\n- Suppression of oncogenic pathways (e.g., Hippo-YAP/TAZ, NOTCH1)