MicroRNA 584 (miR-584)

MicroRNA 584 (miR-584) is a small, non-coding RNA molecule classified as a microRNA that functions as a post-transcriptional regulator of gene expression[5]. It is transcribed as part of a primary miRNA transcript and processed into a mature miRNA that is incorporated into the RNA-induced silencing complex (RISC), guiding the complex to repress target mRNAs through imperfect base pairing, leading to translational inhibition or degradation[5]. Functional studies have established miR-584 as a tumor suppressor in several cancers, where it is frequently downregulated. Overexpression impairs cell proliferation, induces apoptosis, inhibits migration and invasion, and sensitizes cancer cells to chemotherapeutic agents such as vincristine, cisplatin, and taxanes, often through G2/M cell cycle arrest and downregulation of target oncogenes like CCN2, HDAC1, eIF4E3, Rock1, PTTG1IP, and MTDH[1][2][3][4][6]. Decreased miR-584 levels are linked to tumor progression and chemoresistance, indicating biomarker potential for cancer diagnosis, prognosis, and therapy response.\n\nNote: No small molecules or clinically approved drugs act directly on miR-584 as a primary target, but miR-584 mimics or delivery approaches are being explored preclinically as potential therapeutic strategies[1][2].

Other names

MIR584hsa-mir-584MIRN584

Sensitization to chemotherapy (via upregulation, resulting in increased apoptosis and decreased proliferation); overexpression causes G2/M cell cycle arrest and DNA damage; and direct targeting and inhibition of oncogenes (e.g., CCN2, HDAC1, eIF4E3, PTTG1IP, MTDH, ROCK1).