MicroRNA-587 (miR-587)

MicroRNA-587 is a small, non-coding RNA involved in post-transcriptional regulation of mRNA by binding to complementary sequences, predominantly in the 3'UTRs of target genes. In cancer biology, miR-587 is implicated in cell cycle progression, apoptosis regulation, migration, and invasion, with its roles being highly context-dependent. In colorectal cancer, miR-587 drives resistance to 5-fluorouracil-induced apoptosis by targeting PPP2R1B, leading to increased AKT signaling and decreased cell death. Conversely, in hepatocellular carcinoma, miR-587 functions as a tumor suppressor by targeting ribosomal protein SA (RPSA), inhibiting proliferation and invasion. Expression levels and functional roles of miR-587 are variable across tumor types, suggesting its utility as a biomarker for prognosis and therapy response, though its therapeutic targeting presents significant challenges due to its widespread effects and lack of clinical agents directly modulating this miRNA.

Other names

hsa-miR-587MIR587MIRN587hsa-mir-587

For 5-fluorouracil: miR-587 confers resistance by downregulating PPP2R1B, leading to AKT activation and reduced apoptosis. For AKT inhibitors (MK-2206): they overcome miR-587-mediated resistance by blocking downstream AKT phosphorylation. For experimental anti-miR oligonucleotides: they inhibit miR-587 to restore PPP2R1B expression and resensitize to chemotherapy.