microRNA-589 (miR-589)

microRNA-589 (miR-589) is an endogenous small non-coding RNA in humans that regulates target gene expression at the post-transcriptional level, usually through binding to the 3' untranslated regions (UTRs) of specific mRNAs[4]. It has prominent regulatory roles in various biological processes in cancer, where it can function either as a tumor suppressor or oncogene depending on the tissue context[4]. For instance, edited miR-589-3p (by the enzyme ADAR2) in the brain inhibits glioblastoma cell proliferation and invasion by targeting ADAM12, whereas unedited miR-589-3p promotes glioblastoma progression and MMP-9 activity[1]. In triple-negative breast cancer (TNBC), miR-589 acts as a tumor suppressor by inhibiting MTA2 and blocking epithelial-mesenchymal transition (EMT), thus suppressing cell proliferation and migration[2][4]. Its expression or editing state may also serve as a biomarker for cancer diagnosis, prognosis, or therapy selection in diverse tumor types[3][4].

Other names

hsa-mir-589MIR589MIRN589hsa-mir-589-3pmiR-589-3pmir-589-5p

Targets and regulates mRNA stability and translation of genes such as MTA2, PCDH9, ADAM12. Modifies activity depending on RNA editing status (edited vs. unedited miR-589-3p).