microRNA 591 (miR-591)

microRNA 591 (miR-591) is a short non-coding RNA molecule belonging to the microRNA family, involved in post-transcriptional regulation of gene expression by binding to complementary sequences in target mRNAs and promoting their degradation or inhibiting translation[3][5]. miR-591 functions predominantly as a tumor suppressor in several cancer types, especially breast cancer, where it is frequently downregulated[1]. Reduced expression of miR-591 is associated with advanced tumor stage and metastasis. Experimentally increased miR-591 inhibits proliferation and invasion of cancer cells by targeting genes such as TCF4 and modulating major cancer-associated signaling pathways (e.g., Hippo-YAP/TAZ)[1]. While not a protein or classical druggable receptor, miR-591 is considered a promising therapeutic target for cancer therapy development and may also serve as a biomarker for cancer diagnosis or prognosis[1][3][5].

Other names

MIR591hsa-mir-591MIRN591miR-591

Small RNA molecule that binds to complementary sequences in the 3’ untranslated regions (3’ UTR) of target messenger RNAs (mRNAs), leading to repression of gene expression via mRNA degradation or translational inhibition[3][5]. - Specific tumor-suppressor actions mediated by downregulation of oncogenic targets, such as TCF4 and inhibition of Hippo-YAP/TAZ signaling in breast cancer[1].