microRNA-592 (miR-592 (or hsa-miR-592 for human-specific))

microRNA-592 is a small non-coding RNA molecule belonging to the microRNA family that regulates gene expression post-transcriptionally, primarily through binding to target mRNAs and inhibiting translation or promoting degradation. It has been implicated in the regulation of cell proliferation, migration, invasion, differentiation, and pluripotency, with roles that vary between tissue types and disease contexts. In some cancers, such as non-small cell lung cancer, ovarian cancer, hepatocellular carcinoma, thyroid cancer, breast cancer, and glioma, miR-592 acts as a tumor suppressor, inhibiting malignant phenotypes by targeting genes like SOX9, IGF-1R, ERBB3, and NOVA1. In contrast, in cancers such as colorectal and prostate cancers, miR-592 may function as an oncogene, promoting oncogenic phenotypes by downregulating targets such as SPARC. Beyond oncology, miR-592 also participates in neurogenesis and maintenance of stem cell states. MicroRNA-592 is therefore recognized both as a disease biomarker and a potential therapeutic target, but its context-specific activity represents both an opportunity and a challenge for future RNA-based therapies[1][2][3][4][5][6][7].

Other names

hsa-miR-592MIR592MIRN592mir-592hsa-mir-592

Not drug-targeted; acts via RNA-based modulation of target gene translation or stability, for example: - By binding to the 3′UTR of target mRNAs such as SOX9, SPARC, IGF-1R, ERBB3, NOVA1, leading to their downregulation