microRNA 593 (miR-593)

microRNA 593 (miR-593) is a small, non-coding RNA molecule involved in the regulation of gene expression by binding to complementary sequences in the 3′-untranslated regions of specific mRNAs, leading to their post-transcriptional repression or degradation[1][3][5][6]. miR-593 functions as a tumor suppressor in several cancer types, including gastric, lung, and colon cancer, where it inhibits cell proliferation, migration, and invasion, prompts cell cycle arrest, and promotes apoptosis by targeting genes such as MST4 (implicated in the c-Jun/FAK/MMP12 pathway), SLUG (SNAI2, affecting EMT and Akt/cyclin D1/CDK4/6 signaling), and PROP1[1][3][5][6]. In endocrinology, miR-593 is found to be upregulated in children with combined pituitary hormone deficiency, possibly through direct repression of PROP1[6]. As a member of the microRNA family, MIR593 is considered a regulatory, non-coding RNA without direct ligand–receptor or enzyme–substrate interaction, but with important regulatory impact in pathophysiology and disease.

Other names

hsa-mir-593MIRN593MIR593miR-593-5p

Not applicable for classic receptor/enzyme small-molecule drug action; instead, acts via direct binding to 3′-UTR regions of target mRNAs such as MST4, SLUG (SNAI2), and PROP1, leading to their downregulation[1][3][5][6].