MicroRNA-597 (miR-597)

MicroRNA-597 (miR-597) is a small, non-coding RNA molecule classified as a microRNA, involved in the post-transcriptional regulation of gene expression. It acts primarily by binding to complementary sequences in the 3′ untranslated regions (3′UTRs) of target mRNAs, such as FOS-like antigen 2 (FOSL2), leading to mRNA degradation or translational repression[1][3][4]. miR-597 is frequently downregulated in several human cancers, including breast cancer and colorectal cancer, where it functions as a tumor suppressor by inhibiting cell proliferation, migration, invasion, and promoting apoptosis[1][3][4]. In myelodysplastic syndromes, miR-597 is found to be upregulated and induces apoptosis by downregulating FOSL2[4]. Due to its disease associations and role in regulating malignancy-related pathways such as EMT and cell cycle progression, miR-597 (and its expression levels) may serve as a biomarker for diagnosis or prognosis in certain cancers and is considered a potential therapeutic target[1][3][4].

Other names

hsa-miR-597MIR597hsa-mir-597mir-597MIRN597