MicroRNA 601 (miR-601)

MicroRNA 601 (miR-601) is a small non-coding RNA molecule belonging to the microRNA family, which modulates gene expression post-transcriptionally by binding mRNAs, leading to translational inhibition or degradation[7][2][4][5][6]. It acts as a regulatory element in various cellular processes, including translation repression, apoptosis, cell proliferation, migration, and invasion, as well as immune modulation via repression of NF-κB activity[2][3][4]. miR-601 has tumor suppressor properties and is often downregulated in several cancers, with documented roles in prostate, lung, liver, colorectal, gastric, and breast cancers[2][3]. It influences cellular pathways such as Wnt signaling (by targeting keratin 5/KRT5) and apoptotic signaling, impacting cancer cell behavior and metastatic potential[1][2][3][4]. Serum or tissue levels of miR-601 have been studied as candidate biomarkers for cancer diagnosis, prognosis, and treatment response, especially in lung cancer[2][3]. As a member of the highly conserved microRNA family, miR-601 is transcribed from the MIR601 locus and represents a potential therapeutic target for antisense or oligonucleotide-based strategies, although no drugs are currently approved for direct targeting[7][2][5][6].

Other names

MIR601hsa-mir-601MIRN601

Post-transcriptional repression of gene expression via binding to target mRNAs, Suppression of specific signaling pathways (e.g., NF-κB, Wnt signaling, Fas-induced apoptosis), Potential modulation of chemotherapy or targeted therapy response