MicroRNA 610 (miR-610)

MicroRNA 610 (miR-610) is a short, single-stranded non-coding RNA belonging to the microRNA class, involved in the post-transcriptional regulation of gene expression. In humans, miR-610 functions predominantly by base-pairing to complementary sequences in the 3' untranslated regions of target mRNAs, leading mainly to translational inhibition or mRNA degradation. miR-610 acts as a tumor suppressor in several cancer types, such as glioblastoma, melanoma, colorectal cancer, and osteosarcoma, by directly repressing cancer-related genes like cyclin D2 (CCND2), AKT3, LRP6, and hepatoma-derived growth factor (HDGF). Its downregulation is associated with enhanced cell proliferation, invasion, and tumor progression, whereas its overexpression inhibits these processes through effects on cell cycle, apoptosis, and epithelial-mesenchymal transition. The unique ability of circulating miRNAs to serve as disease biomarkers further positions miR-610 as a potential prognostic and diagnostic marker in oncology. As a microRNA, targeting or delivering miR-610 therapeutically faces challenges related to specificity, stability, and minimizing unintended gene regulation.

Other names

hsa-mir-610MIR610MIRN610

Binds to 3'-untranslated region (3'UTR) of specific mRNAs (e.g., CCND2, AKT3, LRP6, HDGF) to repress their expression, inhibiting translation or promoting degradation. Modulates epithelial-mesenchymal transition by upregulating E-cadherin and downregulating vimentin.