MicroRNA 620 (miR-620)

MicroRNA 620 (miR-620) is a small non-coding RNA molecule that regulates gene expression at the post-transcriptional level, primarily through interaction with the 3′UTR of mRNA targets, leading to translational repression or degradation of those targets. It is notably involved in several carcinoma types, where it has been shown to inhibit cell proliferation, migration, invasion, and epithelial-mesenchymal transition in esophageal squamous cell carcinoma (ESCC) by downregulating the transcription factor FOXM1 and thereby suppressing HER2 expression—affecting aerobic glycolysis and metastatic processes. miR-620 is also secreted in exosomal vesicles, enabling regulatory effects on recipient cells in the tumor microenvironment, such as reprogramming fibroblast glycolysis to promote cancer metastasis. The molecule is being explored as both a prognostic biomarker and therapeutic candidate, although clinical application is limited by its broad-ranging effects and challenges in targeted delivery.

Other names

hsa-mir-620MIRN620MIR620

Binds to the 3′UTR of target mRNAs (e.g., FOXM1), leading to mRNA degradation or translational repression. Downregulates FOXM1, which subsequently downregulates HER2, affecting glycolytic activity and possibly metastatic capability in ESCC.