MicroRNA 622 (miR-622)

MicroRNA 622 (miR-622) is a small, non-coding RNA molecule (19–24 nucleotides) that post-transcriptionally regulates gene expression by binding to complementary sequences within the 3' untranslated regions of target mRNAs, leading to mRNA degradation or translational repression. It acts as a tumor suppressor in multiple cancer types, including breast, lung, gastric, liver, colorectal, glioma, and renal cancers, primarily by targeting oncogenic pathways such as K-Ras, NUAK1, RNF8, YAP, and others. miR-622 modulates critical cell functions including proliferation, migration, epithelial-mesenchymal transition, apoptosis, and DNA damage repair. Its expression is frequently downregulated in malignancies, and lower levels are associated with more aggressive disease and poorer prognosis. Therapeutic modulation of miR-622, either through mimics or antagomirs, alters cancer cell behavior and holds potential as a biomarker for diagnosis and prognosis, though safety challenges remain due to complex gene regulatory networks and tissue specificity.

Other names

hsa-miR-622MIRN622MIR622hsa-mir-622

Upregulation of miR-622 can inhibit cancer cell proliferation, invasion, migration, and EMT by repressing target oncogenes such as K-Ras, NUAK1, RNF8, YAP, HIF-1α, CCL18, DYRK2 Downregulation or inhibition can enhance cancer cell survival, proliferation, and migration