MicroRNA 633 (miR-633)

MicroRNA 633 (miR-633) is a small, non-coding RNA (20-24 nucleotides) primarily involved in the post-transcriptional regulation of gene expression by binding to complementary sequences on target messenger RNAs, leading to their translational inhibition or degradation. It is upregulated in malignant melanoma and promotes tumor cell proliferation and migration by directly targeting and suppressing the KAI1/CD82 tumor suppressor gene. miR-633 also shows abnormal expression patterns in acute lymphoblastic leukemia and endometrial carcinoma, suggesting broader relevance in cancer biology and hormone regulation. While no approved drugs target miR-633 directly, its inhibition in model systems reduces tumor cell viability and invasiveness, positioning it as a potential therapeutic target and disease biomarker in oncology.

Other names

miR-633MIR633hsa-mir-633MIRN633

For molecules or inhibitors that target miR-633, the expected mechanisms would include: Antisense oligonucleotide inhibition (anti-miR-633 binds to mature miR-633 and blocks its ability to repress mRNA targets); Small molecule modulation of miR-633 biogenesis or stability. Experimental inhibition of miR-633 increases KAI1/CD82 tumor suppressor expression and suppresses melanoma cell proliferation/migration.