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Target intelligence / Profile preview
MicroRNA 640 (MIR640)
- Target
- MIR640
- Molecular classification
- microRNA (miRNA), Non-coding RNA, RNA gene
01
Overview
MicroRNA 640 (MIR640) is a small, non-coding RNA molecule 20-24 nucleotides in length, encoded by the MIR640 gene in humans. It regulates gene expression post-transcriptionally by binding to the 3′ UTR of target mRNAs, including the Slit guidance ligand 1 (SLIT1), resulting in reduced expression and functional consequences for cell proliferation, adhesion, apoptosis, and radiosensitivity. miR-640 exerts pro-tumorigenic or anti-tumorigenic effects depending on the cellular context, notably enhancing glioma radiosensitivity through the suppression of SLIT1 and the Wnt/β-catenin signaling pathway. Its expression is dysregulated in several diseases, making it of therapeutic and diagnostic interest
- Other names
- hsa-mir-640MIRN640MIR640
02
Mechanism of action
Inhibition of target mRNA translation or stability (SLIT1, beta-catenin, EP300); Suppression of Wnt/β-catenin signaling pathway
03
Biological functions
Post-transcriptional gene silencingRegulation of cell proliferationRegulation of cell adhesionRegulation of apoptosisRegulation of cell cycleModulation of radiosensitivity in glioma
04
Disease associations
Cancer (especially glioblastoma and glioma)Degenerative disc disease (nucleus pulposus degeneration)
05
Safety considerations
No notable safety concerns have been reported; however, as a regulator of multiple pathways, off-target effects and broad regulatory impact are potential therapeutic challenges
06
Biomarkers
Elevated miR-640 may serve as a biomarker for glioblastoma progression and radiosensitivity
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