MicroRNA 642a (MIR642A)

MicroRNA 642a (MIR642A) is a small, non-coding RNA molecule of the microRNA class involved in post-transcriptional regulation of gene expression by targeting mRNA transcripts for translational inhibition or degradation[3]. MIR642A is transcribed as part of capped and polyadenylated primary transcripts, processed by Drosha and Dicer, and is incorporated into RISC complexes to modulate expression of specific target genes[3]. It is highly induced during adipocyte differentiation—particularly the 3p isoform—suggesting a prominent role in human adipogenesis and obesity[1]. MIR642A also functions as a tumor suppressor; overexpression of miR-642a-5p inhibits cell proliferation, migration, invasion, and EMT in prostate and colon cancer by directly downregulating genes such as WT1 and COL1A1[2][4]. In clinical contexts, altered MIR642A expression is associated with diseases including cancer (notably prostate and colon), leiomyoma, and other conditions[3]. No direct drug targeting microRNA 642a has been reported, but it is under investigation as a therapeutic target for cancer and a biomarker of adipogenesis and tumor progression[2][4][1].

Other names

hsa-mir-642MIR642MIRN642hsa-mir-642amir-642amicroRNA 642microRNA mir-642a

Post-transcriptional gene silencing via RNA-induced silencing complex (RISC); Downregulation of target oncogenes (e.g., Wilms Tumor 1 (WT1), COL1A1, DOHH, NUAK1, RASSF3, SKP2); Upregulation of tumor suppressor pathways (e.g., IGFBP3)