MicroRNA 643 (MIR643)

MicroRNA 643 (MIR643) is a short (approximately 20–24 nucleotides) non-coding RNA gene expressed in humans, processed from a longer precursor RNA by Drosha and Dicer enzymes. MIR643 plays a central role in post-transcriptional regulation by guiding the RNA-induced silencing complex (RISC) to repress specific mRNAs, notably targeting the anti-apoptotic X-linked inhibitor of apoptosis protein (XIAP), APOL6, and ZEB1 genes. Upregulation of miR-643 can promote apoptosis, especially in contexts such as cancer (as a tumor suppressor) and in infection response to *Entamoeba histolytica*. It is also implicated in cisplatin resistance via intercellular transfer in exosomes, reducing apoptosis and DNA damage. Clinically, MIR643 is associated with disease processes in cancer and the endometrium, and its modulation is being explored for therapeutic benefit and resistance profiling[1][3][4].

Other names

MIR643hsa-mir-643MIRN643mir-643MIR643 (HGNC: 32899, NCBI Gene: 693228, miRBase: hsa-mir-643)

RNA-induced silencing: via RISC complex, miR-643 pairs with the 3′UTR of target mRNAs, causing translational inhibition or mRNA degradation (notably XIAP, APOL6, ZEB1) Modulation of apoptosis (induces cell death by suppressing anti-apoptotic targets)