MicroRNA 649 (miR-649)

MicroRNA 649 (miR-649) is a small non-coding RNA molecule from the microRNA (miRNA) class involved in the post-transcriptional regulation of gene expression in multicellular organisms [1]. miR-649, like other microRNAs, functions by binding target messenger RNAs (mRNAs) and inducing translational repression or destabilization, commonly through imperfect base-pairing to sites within the 3' untranslated region (UTR) of the mRNA [2][4]. MIR649 is transcribed as part of a primary RNA transcript, processed by Drosha and Dicer into its mature form, and then incorporated into the RNA-induced silencing complex (RISC) to regulate gene expression. Although most miRNAs can regulate hundreds of gene transcripts and are involved in diverse biological processes, direct disease associations for miR-649 are not well characterized except for a reported link to Digeorge syndrome [1]. There is no strong evidence that miR-649 is currently considered a direct therapeutic target, and there are no approved drugs known to interact specifically with this miRNA. **Supporting details:** - MIR649 is listed as a human RNA gene (microRNA, miRNA class) with limited direct disease association; Digeorge syndrome is mentioned [1]. - miRNAs as a class regulate gene expression post-transcriptionally, influencing mRNA stability and translation [1][2][4]. - miR-649 is reported to overlap with three types of repetitive elements: LINE, SINE, and DNA transposon, which is uncommon among human miRNAs [7]. - No known interacting drugs, biomarker usage, or safety concerns specified for this molecule. **Note:** - This entry is correctly classified as a microRNA and not a classical protein-coding therapeutic target (like a receptor or enzyme). Its role is primarily regulatory at the RNA level. - Unless future research identifies it as a druggable target or biomarker, its direct therapeutic relevance remains limited.

Other names

MIR649hsa-mir-649MIRN649