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microRNA-6500-3p (miR-6500-3p)
- Target
- miR-6500-3p
- Molecular classification
- small non-coding RNA, microRNA
01
Overview
microRNA-6500-3p is a human microRNA, a single-stranded, ~22 nucleotide non-coding RNA that post-transcriptionally regulates gene expression by binding to complementary sequences in mRNAs, leading to their repression or degradation. Notably, miR-6500-3p functions as a tumor suppressor in pediatric high-grade glioma (pHGG), where its downregulation permits upregulation of cell cycle genes such as KIF14 and NCAPG. Restoration of miR-6500-3p levels suppresses proliferation of glioma cells, suggesting potential as a future therapeutic or diagnostic target.
- Other names
- hsa-mir-6500hsa-miR-6500-3pmicroRNA mir-6500MIR6500
02
Mechanism of action
Post-transcriptional repression of mRNA targets (notably KIF14 and NCAPG), leading to decreased expression of cell cycle–promoting proteins
03
Biological functions
Regulation of cell cycleControl of cell proliferationPost-transcriptional gene silencing (via mRNA repression/degradation)
04
Disease associations
Cancer (pediatric high-grade glioma)
05
Safety considerations
General challenges of oligonucleotide therapeutics (delivery, stability, off-target effects)Specific miR-6500-3p safety profile data is not known; safety would depend on delivery modality and off-target effects
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