Target intelligence / Profile preview

microRNA 6501 (miR-6501)

Target
miR-6501
Molecular classification
microRNA, non-coding RNA, small regulatory RNA
01

Overview

microRNA 6501 (miR-6501) is a single-stranded, non-coding RNA molecule of ~21-23 nucleotides that belongs to the microRNA (miRNA) family. It is annotated as "hsa-mir-6501" in the human genome. Like other microRNAs, it acts post-transcriptionally to regulate gene expression, usually by binding to complementary sites within target messenger RNAs (mRNAs), leading to mRNA degradation or inhibition of translation[3][4]. miR-6501 specifically has been reported as part of a diagnostic and prognostic microRNA signature in breast cancer and is considered essential for the growth of certain 3D breast cancer tumoursphere models[1]. However, there are no known or validated direct drug interactions, well-characterized targets, or established therapy strategies focusing on miR-6501. Literature on miR-6501 is sparse compared to extensively studied miRNAs. There is no evidence supporting its classification as a therapeutic target (such as a receptor, enzyme, or other druggable protein)[1][3][4].

Other names
hsa-mir-6501mir-6501microRNA mir-6501MIR6501
02

Mechanism of action

not applicable (no drugs known to target this miRNA; general mechanism of miRNAs involves RNA silencing and translational repression)[3][4]

03

Biological functions

post-transcriptional gene regulation (general to all microRNAs)[3][4]possible involvement in tumor growth (specific for miR-6501 in breast cancer models has been reported)[1]
04

Disease associations

possible relevance in cancer (diagnosis, prognosis, and essentiality for certain breast cancer tumoursphere models)[1]otherwise, general microRNA roles in various diseases[3][4]
05

Safety considerations

none specific reported (therapeutic manipulation of miRNAs faces general safety challenges, but none uniquely linked to miR-6501)
06

Interacting drugs

none known (no drugs reported to specifically target miR-6501 as of 2024)
07

Biomarkers

potential biomarker for breast cancer diagnosis and prognosis in research settings[1]no clinical validation

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